Investigation of Inhibition Effects of Honey, Pollen, Propolis and Royal Jelly Extracts on Thioredoxin Reductase Enzyme Activity

Abstract

The thioredoxin reductase enzyme is an enzyme that prevents the mechanism of apoptosis from workingand thus triggers the formation of cancer. Therefore, the inhibition of the thioredoxin reductase enzyme isthought to prevent or inhibit cancer. In this study, the effects of extracts of plateau honey, pine honey,chestnut honey, mad or wild honey, pollen, propolis and royal jelly on thioredoxin reductase enzymeactivity were investigated. Enzyme activities were measured at constant substrate and different inhibitorconcentrations to calculate IC50 values. Total antioxidant activity were investigated in order to compare theextracts used in the inhibition study. The strongest inhibitory effect was seen in the pollen methanol extract(IC50 = 2.44?g /mL)