TROPONIN-1, CK-MB, D-DIMER, AND NT-proBNP LEVELS BEFORE AND AFTER TWO DIFFERENT ANESTHESIA PROTOCOLS IN DOG

Abstract

This study aimed to determine the cardiac effects of two different anesthetic protocols by measuring serum levels of Troponin 1, CK-MB, NT-proBNP and D-Dimer in healthy castrated non cardiac dogs. Thirty adult, healthy, and noncardiac male dogs were brought to the animal hospital affiliated to the Animal Health Application and Research Center of Siirt University for castration. The animals were sedated with intramuscular administration of 2 mg/kg of xylazine HCl and anesthesia was induced by intramuscular administration of 10 mg/kg Ketamine HCl. The animals were intubated and connected to the closed-circuit anesthesia device. Following induction of general anesthesia, dogs were divided into two groups. Group 1 (G1) (n=15) was administered with 2-3% Isoflurane inhaler, the other group (G2) (n=15) was administered with 2-3% Sevoflurane inhaler to maintain anesthesia. Blood samples were collected before and 12 hours after anesthesia. Results revealed non-significant changes in serum levels of CK-MB over time. However, a significant difference was observed in CK-MB values between sevoflurane and isoflurane. No significant changes in Troponin values were recorded. Significant changes in Nt-Pro BNP values over time were observed, but the changes were not significant between anesthetic protocols. With the present study, we can partially say that sevoflurane is safer than isoflurane, but we believe that more studies should be done with more samples. © 2023, Assiut University, Faculty of Veterinary Medicine. All rights reserved.