Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats

Abstract

The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.