Trimester Specific Anatomical and Histological Characterization of Testicular Descent and Development in Sheep Foetuses

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dc.contributor.authorGuzel, Baris Can
dc.contributor.authorKandil, Banu
dc.contributor.authorAtli, Muhammet Zahid
dc.contributor.authorIsbilir, Ihsan
dc.contributor.authorMelnyk, Oleksii O.
dc.contributor.authorIsbilir, Fatma
dc.date.accessioned2026-10-23T18:14:12Z
dc.date.available2026-10-23T18:14:12Z
dc.date.issued2026
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground This study aimed to investigate the morphological, histological and ultrastructural characteristics of prenatal testicular development in male Hamdani crossbred sheep foetuses.Methods A total of 17 male foetuses with gestational ages ranging from 50 to 125 days were examined. Gestational age was estimated using crown-Rectum length (CRL) measurements and the foetuses were classified according to trimester. Macroscopic evaluations were performed to determine the position of the testes in relation to the abdominal cavity, inguinal canal and scrotum. Testicular length, width and weight were measured and statistically analysed. Histological examinations were conducted on paraffin sections stained with Crossmon's trichrome, while ultrastructural features were evaluated using scanning electron microscopy (SEM).Results Testicular descent was observed to begin around Day 50 of gestation and progressed toward the inguinal canal; however, complete descent into the scrotum had not occurred by Day 125. Morphometric measurements showed a significant increase in testicular size and weight with advancing gestational age. Histological findings revealed the progressive formation and organization of seminiferous tubules, the presence of Sertoli and Leydig cells, and the development of interstitial tissue. SEM observations provided detailed visualization of the surface architecture and cellular organization of the developing foetal testes.Conclusion This study provides a comprehensive developmental timeline of testicular organogenesis in Hamdani crossbred sheep foetuses. The findings contribute to the understanding of foetal reproductive biology and offer valuable anatomical data for comparative developmental studies and the evaluation of congenital testicular disorders.
dc.identifier.doi10.1002/vms3.71214
dc.identifier.issn2053-1095
dc.identifier.issue5
dc.identifier.pmid42722612
dc.identifier.scopus2-s2.0-105050203725
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/vms3.71214
dc.identifier.urihttps://hdl.handle.net/20.500.12604/12331
dc.identifier.volume12
dc.identifier.wosWOS:001872160800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofVeterinary Medicine and Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20261017
dc.subjectFoetal Testis
dc.subjectHamdani Crossbred Sheep
dc.subjectHistology
dc.subjectPrenatal Testicular Development
dc.subjectScanning Electron Microscopy (Sem)
dc.subjectTesticular Descent
dc.titleTrimester Specific Anatomical and Histological Characterization of Testicular Descent and Development in Sheep Foetuses
dc.typeArticle

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