Comparative detection of selection signatures in indigenous and crossbred Turkish sheep breeds

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dc.authorid0000-0003-2705-2831
dc.authorid0000-0003-3268-864X
dc.authorid0000-0002-7130-8796
dc.contributor.authorBayraktar, Mervan
dc.contributor.authorDogan, Sukru
dc.contributor.authorKirbas, Mesut
dc.contributor.authorBulbul, Bulent
dc.contributor.authorYaman, Yalcin
dc.date.accessioned2026-03-14T11:48:51Z
dc.date.available2026-03-14T11:48:51Z
dc.date.issued2025
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aimed to comparatively detect genomic signatures of selection in indigenous and crossbred Turkish sheep breeds using medium-density SNP genotyping. A total of 1612 individuals were analyzed, comprising the indigenous Akkaraman breed and four crossbreds: Karacabey Merino, Oamer, Hasak, and Hasmer. PCA revealed clear genetic separation ofAkkaraman, partial overlap between Karacabey Merino and Oamer, and distinct variation in the small Hasak and Hasmer populations. Genetic diversity metrics indicated moderate, relatively homogeneous diversity across breeds, with slightly negative FIS values, reflecting heterozygote excess. Selection signatures were identified using ROH, iHS, and Tajima's D statistics. ROH analysis highlighted breed-specific candidate genes associated with growth (e.g., BGLAP, MYF6, GHR), milk production (PRL, LTF, casein cluster), immune response (TLR2, TLR5, IL15), and reproduction (FSHB, BMPR1B). iHS detected additional loci under positive selection, including MSTN, POU1F1, LEPR, and LALBA, while Tajima's D identified selective sweeps in genes related to muscle development (CAPN2, CAST), reproduction (PAG4), and immune function (IRF2, ITGB2). Fifty candidate genes were shared among all breeds, whereas others were breed-specific, suggesting both common and unique adaptive pathways. These findings provide valuable insights into the genomic architecture and adaptive evolution of indigenous and crossbred Turkish sheep, with implications for conservation and breeding strategies.
dc.description.sponsorshipTarimsal Arascedil;tirmalar ve Politikalar Genel Mdrlgbreve;, Trkiye Cumhuriyeti Tarim Ve Orman Bakanligbreve;i [TAGEM/HAYSD/E/20/A4/P2/2141]
dc.description.sponsorshipThe authors express their gratitude to the General Directorate of Agricultural Research and Policies for invaluable support. We also express our gratitude to our great leader, Mustafa Kemal ATATURK, who stated that Science is the truest guide in the world for everything - for life, for success.
dc.identifier.doi10.1038/s41598-025-29969-1
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid41276594
dc.identifier.scopus2-s2.0-105026217039
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-025-29969-1
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8989
dc.identifier.volume15
dc.identifier.wosWOS:001651216300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260310
dc.subjectTurkish Sheep
dc.subjectSelection Signatures
dc.subjectRoh
dc.subjectIhs
dc.subjectTajima'S D
dc.subjectGenetic Diversity
dc.titleComparative detection of selection signatures in indigenous and crossbred Turkish sheep breeds
dc.typeArticle

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