Insecticidal Potential of Essential Oils from Origanum onites, Lavandula angustifolia, and Foeniculum vulgare Against Agonoscena pistaciae: Integrated In Vitro and In Silico Approaches

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dc.contributor.authorYas, Cemile
dc.contributor.authorDilmen, Halil
dc.contributor.authorGok, Mesut
dc.contributor.authorBasar, Yunus
dc.date.accessioned2026-10-23T18:14:14Z
dc.date.available2026-10-23T18:14:14Z
dc.date.issued2026
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study evaluated the insecticidal potential of essential oils (EOs) obtained from Origanum onites, Lavandula angustifolia, and Foeniculum vulgare against Agonoscena pistaciae. The phytochemical content of the essential oils was determined by GC-MS. Furthermore, molecular docking analyses were performed to theoretically investigate the inhibitory properties of the dominant compounds against the detoxification enzymes glutathione S-transferase (GST) and cytochrome P450. In the GC-MS analysis, the dominant components were identified as follows: O. onites (60.51% carvacrol, 9.73% linalool, and 7.53% cis-cymene); L. angustifolia (25.44% linalyl acetate, 23.47% linalool, and 7.37% cis-cymene); and F. vulgare (49.41% anethol, 14.62% p-anisaldehyde, and 9.35% estragol). As a result of molecular docking, carvacrol showed the strongest binding affinity to both enzymes, surpassing the reference inhibitors metronidazole and coniferil ferulate, achieving docking scores of -5.40 kcal/mol and -5.70 kcal/mol, respectively. Visualization of molecular interactions revealed strong hydrogen bonds and hydrophobic contacts between carvacrol and the enzyme active sites. Biological analyses confirmed that carvacrol-rich O. onites EOs caused significantly higher mortality rates in A. pistaciae larvae compared to other applications and controls. These results demonstrate that carvacrol derived from O. onites is a promising natural insecticide targeting detoxification enzymes in pests and offering a sustainable alternative to synthetic pesticides.
dc.description.sponsorshipScience and Technology Application and Research Center of Siirt University -- The authors would like to express their sincere appreciation to the Science and Technology Application and Research Center of Siirt University for facilitating the RSH/GC-MS analysis. This study is derived from the completed MSc thesis of the first author.
dc.identifier.doi10.1002/cbdv.202503318
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue5
dc.identifier.orcid0000-0002-7785-3242
dc.identifier.pmid42087407
dc.identifier.scopus2-s2.0-105037886049
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202503318
dc.identifier.urihttps://hdl.handle.net/20.500.12604/12348
dc.identifier.volume23
dc.identifier.wosWOS:001756888600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20261017
dc.subjectAgonoscena Pistaciae
dc.subjectCarvacrol
dc.subjectGlutathione S-Transferase
dc.subjectIn Silico
dc.subjectInsecticidal
dc.subjectMolecular Docking
dc.titleInsecticidal Potential of Essential Oils from Origanum onites, Lavandula angustifolia, and Foeniculum vulgare Against Agonoscena pistaciae: Integrated In Vitro and In Silico Approaches
dc.typeArticle

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